Beginning 46 years after the titular cataclysm event, The Lightfall. This event threw the land of Arrak into chaos; destroying cities, ruining crops and awakening monsters all across the continent. The campaign follows a group of adventurers who meet by chance, and quickly form a strong bond, going on to help the people of Arrak, as well as discovering and confronting their individual pasts.

The campaign follows the rise to heroism of a group of adventurers who become known as The Stormchasers. They meet as travellers on an airship voyage across Aerois: a planet left splintered by the effects of an interplanar invasion by the powerful Magitek-weilding Emperor Starbane and the war-ending sacrifice of the goddess Siaska five hundred years ago. Siaska's final creation of The Cradle, an aurora-like protective barrier around the planet, was successfully able to seal Aerois safely off from the rest of the planes. However, not all has been forgotten. When their airship is attacked by mysterious figures remeniscent of Starbane's old forces, the adventurers must band together to continue to survive.

The campaign follows a group of archaeologists in Chult who are searching for treasure and ancient artefacts.

The campaign follows a group of antiheroes in Thay who are looking to find out more about The Death Curse and who or what is causing it. The campaign is Mark’s interpretation of the events preceding Tomb of Annihilation, involving the Death Curse and how various factions obtained the information they have at the beginning of the module. It is described as an anti-hero campaign, akin to Rogue One: A Star Wars Story.

The campaign follows a "Mission: Impossible"-style team from the Harpers, with all player characters having at least one level in the Rogue class.